The Rapid Mixer Granulator (RMG) is a commonly used equipment in the pharmaceutical industry for wet granulation process.
Mixing speed and time: The RMG uses a high-speed mixing blade that rotates at a predetermined speed and time to blend the powders and liquids uniformly. This helps ensure that the particles are evenly distributed throughout the mixture, which is critical for achieving a controlled particle size distribution.
Chopper speed and time: The RMG also has a chopper blade that rotates at a high speed to break down any large agglomerates or lumps that may have formed during the mixing process. The chopper speed and time can be adjusted to achieve the desired particle size distribution.
Wet mass consistency: The consistency of the wet mass is crucial in determining the final particle size distribution. The RMG controls the wet mass consistency by adjusting the amount of liquid added to the mixture and the mixing time.
Sieve size and shape: The RMG has a built-in sieve that separates the granules from any remaining fine particles. The size and shape of the sieve can be customized to achieve the desired particle size distribution.
Granulation time: The RMG can be programmed to granulate for a specific amount of time to ensure that the particles have reached the desired size distribution.
Overall, by controlling the mixing speed, chopper speed, wet mass consistency, sieve size and shape, and granulation time, the RMG can produce granules with a controlled particle size distribution.